Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328272 | 0.99 | KMT2A (0.67) | KMT2AMEN1SIGMAR1HRH3NPC1 | |
| SCHEMBL8328048 | 0.87 | KMT2A (0.68) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL2830939 | 0.87 | KMT2A (0.58) | KMT2AMEN1SIGMAR1HRH3TDP1 | |
| SCHEMBL14218028 | 0.86 | KMT2A (0.76) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL5679866 | 0.85 | KMT2A (0.74) | KMT2AMEN1SIGMAR1KDM4EALOX15 | |
| SCHEMBL4378376 | 0.85 | KMT2A (0.63) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL4375726 | 0.84 | KMT2A (0.65) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL4375454 | 0.84 | KMT2A (0.61) | KMT2AMEN1SIGMAR1HRH3CHRM2 | |
| SCHEMBL2236754 | 0.84 | KMT2A (0.72) | KMT2AMEN1SIGMAR1KDM4EALOX15 | |
| SCHEMBL4377435 | 0.82 | KMT2A (0.61) | KMT2AMEN1SIGMAR1NPC1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253734-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |