Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22813637 | 0.99 | KMT2A (0.69) | KMT2AMEN1SIGMAR1HRH3TDP1 | |
| SCHEMBL8328048 | 0.86 | KMT2A (0.68) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL2830939 | 0.86 | KMT2A (0.58) | KMT2AMEN1SIGMAR1HRH3TDP1 | |
| SCHEMBL2236754 | 0.85 | KMT2A (0.72) | KMT2AMEN1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4375726 | 0.85 | KMT2A (0.65) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL14218028 | 0.85 | KMT2A (0.76) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| SCHEMBL5679866 | 0.84 | KMT2A (0.74) | KMT2AMEN1SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL4378376 | 0.83 | KMT2A (0.63) | KMT2AMEN1SIGMAR1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL4375454 | 0.82 | KMT2A (0.61) | KMT2AMEN1SIGMAR1HRH3CHRM2 | |
| SCHEMBL4377435 | 0.81 | KMT2A (0.61) | KMT2AMEN1SIGMAR1NPC1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |