Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 7/20 | 0.37 |
| ▸ | CTSK | P43235 | 7/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1444341 | 0.86 | MEN1 (0.49) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL23418149 | 0.85 | MEN1 (0.44) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL25789921 | 0.85 | TDP1 (0.41) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL16295315 | 0.84 | MEN1 (0.47) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL2623719 | 0.83 | TDP1 (0.40) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL20057034 | 0.81 | MEN1 (0.38) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL21065336 | 0.80 | TDP1 (0.52) | MEN1GAAKMT2ATDP1MAOA | |
| SCHEMBL3520746 | 0.79 | TDP1 (0.44) | MEN1GAAKMT2ATDP1CTSK | |
| SCHEMBL24716421 | 0.78 | MEN1 (0.38) | MEN1GAAKMT2ATDP1CTSS | |
| SCHEMBL18857615 | 0.78 | TDP1 (0.38) | MEN1GAAKMT2ATDP1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021136808-A1 | CONJUGATES UNDERGOING INTRAMOLECULAR REARRANGEMENTS | ASCENDIS PHARMA A/S (DK) | 2021-07-08 | — | — | WO | disclosed |
| WO-2020254617-A1 | ANTI-CTLA4 COMPOUNDS WITH LOCALIZED PK PROPERTIES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254607-A1 | ANTI-CTLA4 COMPOUNDS WITH LOCALIZED PD PROPERTIES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254611-A1 | ANTI-CTLA4 CONJUGATES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |