Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22815669 | 0.90 | CYP19A1 (0.56) | CYP19A1HPGDGABRA2GABRB2KDM4E | |
| SCHEMBL22815947 | 0.90 | AKR1C3 (0.45) | MAPTKMT2AMEN1POLBGAA | |
| SCHEMBL22816474 | 0.89 | MEN1 (0.46) | CYP19A1HPGDKDM4EMAPTALDH1A1 | |
| SCHEMBL22816547 | 0.87 | CYP19A1 (0.47) | CYP19A1HPGDGABRA2GABRB2KDM4E | |
| SCHEMBL21296878 | 0.85 | MEN1 (0.51) | CYP19A1HPGDKDM4EMAPTALDH1A1 | |
| SCHEMBL22816685 | 0.85 | CYP19A1 (0.46) | CYP19A1HPGDGABRA2GABRB2MAPT | |
| SCHEMBL22816677 | 0.85 | CYP19A1 (0.64) | CYP19A1HPGDGABRA2GABRB2KDM4E | |
| SCHEMBL22816734 | 0.85 | CYP19A1 (0.48) | CYP19A1HPGDKDM4EMAPTALDH1A1 | |
| SCHEMBL22816573 | 0.84 | MEN1 (0.49) | CYP19A1HPGDKDM4EMAPTALDH1A1 | |
| SCHEMBL22816857 | 0.82 | CYP19A1 (0.48) | CYP19A1HPGDGABRA2GABRB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |