Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22827795 | 0.82 | CYP3A4 (0.40) | MEN1KMT2ACHRM1ALDH1A1HPGD | |
| SCHEMBL7725268 | 0.79 | MEN1 (0.43) | MEN1FAAHMAPK1KMT2ATSHR | |
| SCHEMBL23475900 | 0.79 | MEN1 (0.43) | MEN1FAAHMAPK1KMT2ATSHR | |
| SCHEMBL24040864 | 0.78 | CA1 (0.44) | MEN1FAAHMAPK1KMT2ACA1 | |
| SCHEMBL858940 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4708611 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1 | |
| SCHEMBL19414066 | 0.76 | KMT2A (0.41) | MEN1FAAHMAPK1KMT2ATSHR | |
| SCHEMBL17991738 | 0.75 | ALDH1A1 (0.41) | CHRM5CHRM3CHRM1ALDH1A1DPP4 | |
| SCHEMBL22819447 | 0.75 | MEN1 (0.41) | MEN1FAAHMAPK1KMT2ATSHR | |
| SCHEMBL25128749 | 0.75 | CYP2D6 (0.45) | KMT2AALDH1A1MMP1MMP8HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020254609-A1 | TYROSINE KINASE INHIBITOR CONJUGATES | Ascendis Pharma Oncology Division A/S (DK) | 2020-12-24 | — | — | WO | disclosed |