SCHEMBL22823930

SCHEMBL22823930

CCS(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12

nearest known ligand 0.78

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.78
▸ KAT6A Q92794 20/20 0.78
▸ KAT6B Q8WYB5 13/20 0.78
▸ KAT5 Q92993 13/20 0.78
▸ KAT8 Q9H7Z6 13/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22823836 0.93 KAT7 (0.79) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24667503 0.91 KAT7 (0.71) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24668061 0.89 KAT6A (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22823815 0.88 KAT6A (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22823825 0.88 KAT6A (0.67) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22823850 0.88 KAT6A (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22823703 0.88 KAT6A (0.69) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22823967 0.88 KAT6A (0.73) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22802418 0.88 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817406 0.88 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020254989-A1 CYCLOALKYL AND HETEROCYCLOALKYL BENZISOXAZOLE SULFONAMIDE DERIVATIVES PFIZER INC. (US) 2020-12-24 — — WO disclosed
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