SCHEMBL22802418

SCHEMBL22802418

COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OC)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KAT7 O95251 20/20 1.00
KAT6A Q92794 20/20 1.00
KAT6B Q8WYB5 15/20 1.00
KAT5 Q92993 15/20 1.00
KAT8 Q9H7Z6 15/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30637010 0.96 KAT7 (0.92) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817397 0.95 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22828463 0.94 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL29490376 0.94 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL32681126 0.94 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866458 0.94 KAT7 (0.88) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22802430 0.94 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22802536 0.94 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22828657 0.93 KAT7 (1.00) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30360830 0.93 KAT7 (0.87) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4667055-A2 KAT6 INHIBITOR METHODS AND COMBINATIONS FOR CANCER TREATMENT Pfizer Inc. (US) 2025-12-24 EP claimed
EP-4181920-A1 KAT6 INHIBITOR METHODS AND COMBINATIONS FOR CANCER TREATMENT Pfizer Inc. (US) 2023-05-24 EP claimed
CN-116113407-A KAT6 inhibitor methods and combinations for cancer treatment 辉瑞公司 2023-05-12 CN claimed
US-20260062406-A1 Benzisoxazole Sulfonamide Derivatives PFIZER (US) 2026-03-05 US disclosed
EP-4667055-A2 KAT6 INHIBITOR METHODS AND COMBINATIONS FOR CANCER TREATMENT Pfizer Inc. (US) 2025-12-24 EP disclosed
EP-4181920-B1 KAT6 INHIBITOR AND COMBINATIONS FOR BREAST CANCER TREATMENT PFIZER (US) 2025-09-10 EP disclosed
EP-4299135-B1 BENZISOXAZOLE SULFONAMIDE DERIVATIVES PFIZER (US) 2025-08-06 EP disclosed
US-12371425-B2 Benzisoxazole sulfonamide derivatives PFIZER INC. (US) 2025-07-29 US disclosed
EP-3986890-B9 BENZISOXAZOLE SULFONAMIDE DERIVATIVES PFIZER (US) 2025-04-16 EP disclosed
CN-114364672-B Benzisoxazole sulfonamide derivatives 辉瑞大药厂 2024-09-06 CN disclosed
EP-4299135-A2 BENZISOXAZOLE SULFONAMIDE DERIVATIVES Pfizer Inc. (US) 2024-01-03 EP disclosed
CN-116113407-A KAT6 inhibitor methods and combinations for cancer treatment 辉瑞公司 2023-05-12 CN disclosed
US-11492346-B2 Benzisoxazole sulfonamide derivatives PFIZER INC. (US) 2022-11-08 US disclosed
EP-3986890-A1 BENZISOXAZOLE SULFONAMIDE DERIVATIVES Pfizer Inc. (US) 2022-04-27 EP disclosed
CN-114364672-A Benzisoxazole sulfonamide derivatives 辉瑞大药厂 2022-04-15 CN disclosed
WO-2022013369-A1 KAT6 INHIBITOR METHODS AND COMBINATIONS FOR CANCER TREATMENT PFIZER INC. (US) 2022-01-20 WO disclosed
WO-2020254946-A1 BENZISOXAZOLE SULFONAMIDE DERIVATIVES PFIZER INC. (US) 2020-12-24 WO disclosed
US-20200399258-A1 Benzisoxazole Sulfonamide Derivatives PFIZER INC. 2020-12-24 US disclosed
WO-2020254946-A1 BENZISOXAZOLE SULFONAMIDE DERIVATIVES PFIZER INC. (US) 2020-12-24 WO disclosed
US-20200399258-A1 Benzisoxazole Sulfonamide Derivatives PFIZER INC. 2020-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371425-B2 Benzisoxazole sulfonamide derivatives BRIX1, RB1, BCR KAT7 1841/4885KAT6A 3700/4885KAT6B 2765/4885
US-20200399258-A1 Benzisoxazole Sulfonamide Derivatives BRIX1, RB1, BCR KAT7 1917/4885KAT6A 3783/4885KAT6B 2859/4885
US-11492346-B2 Benzisoxazole sulfonamide derivatives BRIX1, RB1, BCR KAT7 1841/4885KAT6A 3700/4885KAT6B 2765/4885
US-20260062406-A1 Benzisoxazole Sulfonamide Derivatives KAT8, KAT5, KAT7 KAT7 3/4885KAT6A 7/4885KAT6B 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.