SCHEMBL22824972

SCHEMBL22824972

c1ccc(-c2ccc3[nH]c4cccc5c4c3c2-c2cccc3cccc-5c23)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 6/20 0.49
CCND1 P24385 6/20 0.49
MAPK1 P28482 4/20 0.42
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.42
HSD17B10 Q99714 2/20 0.42
ATM Q13315 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CASP1 P29466 2/20 0.39
CASP7 P55210 2/20 0.39
HPGD P15428 2/20 0.39
TP53 P04637 1/20 0.39
HIF1A Q16665 1/20 0.39
PLK4 O00444 1/20 0.38
MAPK9 P45984 1/20 0.38
LIMK1 P53667 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
AKT3 Q9Y243 1/20 0.38
CCNB2 O95067 1/20 0.38
CCNE2 O96020 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21650714 0.86 CDK4 (0.47) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL137707 0.85 CDK4 (0.57) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL17324868 0.79 PARP1 (0.53) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL20653095 0.79 ALDH1A1 (0.54) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL22824979 0.79 ALDH1A1 (0.59) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL23068527 0.77 ALDH1A1 (0.58) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL31107073 0.77 ALDH1A1 (0.58) CDK4CCND1MAPK1ALDH1A1TSHR
SCHEMBL21765723 0.77 CDK4 (0.60) CDK4CCND1MAPK1ALDH1A1HSD17B10
SCHEMBL30174980 0.77 CDK4 (0.60) CDK4CCND1MAPK1ALDH1A1HSD17B10
SCHEMBL28015812 0.77 PARP1 (0.47) CDK4CCND1MAPK1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020256376-A1 ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD. (KR) 2020-12-24 WO disclosed