⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25459934 | 0.80 | MAPK1 (0.30) | — | |
| SCHEMBL25459933 | 0.80 | MAPK1 (0.30) | — | |
| SCHEMBL1468931 | 0.78 | DNM1 (0.31) | — | |
| SCHEMBL22828502 | 0.77 | — | — | |
| SCHEMBL12216229 | 0.75 | — | — | |
| SCHEMBL24658663 | 0.75 | DNM1 (0.31) | — | |
| SCHEMBL17641574 | 0.74 | MAPK1 (0.39) | — | |
| SCHEMBL12858992 | 0.72 | MAPK1 (0.33) | — | |
| SCHEMBL20026864 | 0.72 | DNM1 (0.32) | — | |
| SCHEMBL13538326 | 0.72 | MAPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230272384-A1 | METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF RETINOCHISIN 1 (RS1) | KORRO BIO, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230272377-A1 | METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 (TMC1) | KORRO BIO, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230257752-A1 | METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE SYNTHETASE (ASS1) | KORRO BIO, INC. | 2023-08-17 | — | — | US | disclosed |
| US-20230212569-A1 | METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF OTOFERLIN (OTOF) | KORRO BIO, INC. | 2023-07-06 | — | — | US | disclosed |
| US-20200399303-A1 | RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF | KORRO BIO, INC. | 2020-12-24 | — | — | US | disclosed |