Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 19/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1492027 | 0.92 | CYP2C9 (0.50) | CYP2C9CYP3A4CYP2C19BRAFKCNH2 | |
| SCHEMBL1437671 | 0.81 | CYP3A4 (0.68) | CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL1437637 | 0.79 | PSIP1 (0.56) | CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL1462138 | 0.79 | BRAF (0.46) | CYP2C9CYP3A4CYP2C19BRAFKCNH2 | |
| SCHEMBL1462087 | 0.79 | BRAF (0.49) | CYP2C9CYP3A4CYP2C19BRAFKCNH2 | |
| SCHEMBL14574657 | 0.75 | BRAF (0.45) | CYP2C9CYP3A4CYP2C19BRAFRAF1 | |
| SCHEMBL1492043 | 0.75 | BRAF (0.43) | CYP2C9CYP3A4CYP2C19BRAFKCNH2 | |
| SCHEMBL3019846 | 0.74 | CYP3A4 (0.49) | CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL10129555 | 0.74 | CYP3A4 (0.49) | CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL9930589 | 0.74 | BRAF (0.54) | CYP2C9CYP3A4CYP2C19BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020261156-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | ARRAY BIOPHARMA INC. (US) | 2020-12-30 | — | — | WO | disclosed |