Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.76 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.76 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26351079 | 0.88 | IRAK4 (0.58) | IRAK4CRBNFLT3 | |
| SCHEMBL22835099 | 0.86 | IRAK4 (1.00) | IRAK4CRBNIRAK1KCNH2 | |
| SCHEMBL17785215 | 0.83 | IRAK4 (0.80) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL22835560 | 0.83 | IRAK4 (0.75) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785198 | 0.82 | IRAK4 (0.81) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785208 | 0.81 | IRAK4 (0.81) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL19680110 | 0.80 | IRAK4 (0.76) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL21194960 | 0.80 | IRAK4 (0.76) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL16845781 | 0.80 | IRAK4 (0.74) | IRAK4FLT3 | |
| SCHEMBL17785227 | 0.78 | IRAK4 (0.78) | IRAK4FLT3IRAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240059674-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-02-22 | — | — | US | disclosed |
| US-20230303526-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-09-28 | — | — | US | disclosed |
| US-20230069104-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| EP-3989966-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240059674-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885CRBN 187/4885FLT3 60/4885 |
| US-20230069104-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK4, IRAK2, IRAK3 | IRAK4 1/4885CRBN 322/4885FLT3 201/4885 |
| US-20230303526-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885CRBN 187/4885FLT3 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.