Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082612 | 0.86 | GAA (0.46) | CFTRGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL21857249 | 0.85 | GAA (0.50) | CFTRGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL26236304 | 0.85 | GAA (0.50) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL2849661 | 0.84 | CFTR (0.45) | CFTRGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL11922634 | 0.84 | CFTR (0.49) | CFTRGAAHPGDALDH1A1ABL1 | |
| SCHEMBL12683792 | 0.84 | HPGD (0.51) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL12488367 | 0.81 | CFTR (0.43) | CFTRGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL10200826 | 0.81 | CFTR (0.46) | CFTRGAASMN1; SMN2SOS1POLB | |
| SCHEMBL19947385 | 0.81 | CFTR (0.46) | CFTRGAAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL9617792 | 0.81 | CA12 (0.44) | GAAHPGDALDH1A1SMN1; SMN2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2022-08-18 | — | — | US | disclosed |
| WO-2020257940-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020257940-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | APP, AQP4, BACE1 | CFTR 383/4885GAA 297/4885HPGD 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.