Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ADH1B | P00325 | 3/20 | 0.44 |
| ▸ | ADH1A | P07327 | 3/20 | 0.44 |
| ▸ | ADH7 | P40394 | 3/20 | 0.44 |
| ▸ | ADH1C | P00326 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23585070 | 0.83 | NAMPT (0.39) | NAMPTADH1BADH1AADH7ADH1C | |
| SCHEMBL22837680 | 0.82 | TSHR (0.43) | ADH1BADH1AADH7ADH1CMEN1 | |
| SCHEMBL23471072 | 0.82 | FAAH (0.62) | NAMPTMEN1KMT2AFAAHEPHX1 | |
| SCHEMBL22525932 | 0.80 | KDM4E (0.50) | NAMPTMEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL23713358 | 0.80 | FAAH (0.66) | NAMPTMEN1KMT2AFAAHEPHX1 | |
| SCHEMBL19634436 | 0.80 | FAAH (0.66) | NAMPTMEN1KMT2AFAAHEPHX1 | |
| SCHEMBL23471218 | 0.80 | NAMPT (0.47) | NAMPTMEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL22526314 | 0.80 | KDM4E (0.56) | NAMPTMEN1KMT2AFAAHALDH1A1 | |
| SCHEMBL19634653 | 0.80 | FAAH (0.66) | NAMPTMEN1KMT2AFAAHEPHX1 | |
| SCHEMBL13296412 | 0.80 | FAAH (0.55) | NAMPTMEN1KMT2AFAAHEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874743-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874743-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | NAMPT 1694/4885ADH1B 3094/4885ADH1A 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.