Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LGALS3 | P17931 | 5/20 | 0.40 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.40 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.36 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21415335 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL21251634 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL21251844 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL21893892 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL21251598 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL22593278 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL23735725 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL21894556 | 1.00 | ALDH1A1 (0.47) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL23571916 | 0.88 | ALDH1A1 (0.53) | ALDH1A1THRBMAPK1LGALS3LGALS1 | |
| SCHEMBL22296868 | 0.88 | MAPK1 (0.51) | ALDH1A1THRBMAPK1LGALS3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3757215-A2 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2020-12-30 | — | — | EP | disclosed |