Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.48 |
| ▸ | MTOR | P42345 | 11/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.46 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9619196 | 0.84 | KDM4E (0.58) | PIK3CAMTORPIK3CGSMN1; SMN2MAPK1 | |
| SCHEMBL21030137 | 0.84 | MAPT (0.49) | PIK3CAMTORPIK3CGSMN1; SMN2MAPK1 | |
| SCHEMBL12110268 | 0.80 | KMT2A (0.56) | PIK3CAPIK3CGSMN1; SMN2MAPK1LMNA | |
| SCHEMBL29880240 | 0.78 | PIK3CA (0.52) | PIK3CAMTORPIK3CGRICTORRPTOR | |
| SCHEMBL1408578 | 0.78 | PIK3CA (0.52) | PIK3CAMTORPIK3CGRICTORRPTOR | |
| SCHEMBL23505749 | 0.78 | PIK3CA (0.49) | PIK3CAMTORPIK3CGSMN1; SMN2MAPK1 | |
| SCHEMBL15386410 | 0.78 | ALDH1A1 (0.62) | PIK3CAPIK3CGSMN1; SMN2MAPK1LMNA | |
| SCHEMBL21375722 | 0.76 | PIK3CA (0.47) | PIK3CAMTORPIK3CGRICTORRPTOR | |
| SCHEMBL23505765 | 0.75 | MTOR (0.39) | PIK3CAMTORPIK3CGRICTORRPTOR | |
| SCHEMBL22838509 | 0.75 | MTOR (0.55) | PIK3CAMTORPIK3CGRICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458067-B1 | TREATMENT OF NEUROLOGICAL DISORDERS | PIQUR THERAPEUTICS AG (CH) | 2020-12-30 | — | — | EP | disclosed |