Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22840577 | 0.83 | CA12 (0.40) | LMNAALDH1A1HDAC6HDAC4HDAC8 | |
| SCHEMBL5647859 | 0.78 | HDAC6 (0.46) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL14930175 | 0.78 | ERN1 (0.54) | ALDH1A1KCNH2 | |
| SCHEMBL21017950 | 0.77 | HDAC6 (0.67) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL2564176 | 0.77 | ALDH1A1 (0.54) | LMNAALDH1A1NFKB1CA9CA12 | |
| SCHEMBL20982609 | 0.77 | HDAC6 (0.52) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL2569073 | 0.77 | ERN1 (0.50) | ALDH1A1 | |
| SCHEMBL22840334 | 0.75 | ERN1 (0.37) | HDAC6 | |
| SCHEMBL5649064 | 0.74 | HDAC6 (0.46) | LMNAALDH1A1SLC22A2SLC22A1TSHR | |
| SCHEMBL28296530 | 0.72 | GSK3B (0.43) | LMNAALDH1A1TSHRACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |