Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23188312 | 0.79 | APP (0.50) | LMNAMAPTTP53APPRAB9A | |
| SCHEMBL14924962 | 0.75 | ERN1 (0.62) | ERN1MAPT | |
| SCHEMBL12674867 | 0.66 | ERN1 (0.71) | ERN1 | |
| SCHEMBL12767092 | 0.66 | ERN1 (1.00) | ERN1SMN1; SMN2 | |
| SCHEMBL6013714 | 0.65 | MAPT (0.60) | LMNAMAPTTP53RAB9ASMN1; SMN2 | |
| SCHEMBL15985474 | 0.64 | HDAC6 (0.55) | LMNAMAPTTP53SMN1; SMN2 | |
| SCHEMBL14924961 | 0.64 | ERN1 (0.51) | ERN1MAPTTP53RAB9ASMN1; SMN2 | |
| SCHEMBL8325747 | 0.63 | RAB9A (0.43) | ERN1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14538231 | 0.63 | NPC1 (0.66) | LMNARAB9ASMN1; SMN2 | |
| SCHEMBL29951315 | 0.63 | ERN1 (0.66) | ERN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |