Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | RECQL | P46063 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | HMGCR | P04035 | 2/20 | 0.65 |
| ▸ | FASN | P49327 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28052190 | 0.86 | HMGCR (0.83) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL14930208 | 0.83 | HMGCR (0.54) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL30406452 | 0.83 | HMGCR (0.54) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL2552967 | 0.83 | HMGCR (0.54) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL21475691 | 0.82 | HMGCR (0.57) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL14930209 | 0.82 | HMGCR (0.53) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL43001 | 0.81 | ALOX15 (1.00) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL29430367 | 0.81 | ALOX15 (1.00) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL27997509 | 0.80 | HMGCR (0.57) | HPGDRECQLHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL8824020 | 0.77 | HMGCR (0.54) | HPGDRECQLHSD17B10ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |