Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.88 |
| ▸ | POLB | P06746 | 2/20 | 0.88 |
| ▸ | MAPT | P10636 | 2/20 | 0.88 |
| ▸ | GLA | P06280 | 2/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.88 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.88 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.88 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.88 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.88 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.88 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.88 |
| ▸ | RECQL | P46063 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738070 | 0.94 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL18310362 | 0.94 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| Hydrochloric Acid SCHEMBL17476487 | 0.94 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL25932533 | 0.87 | TOP1 (0.86) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL8078009 | 0.86 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL17285701 | 0.85 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL20503262 | 0.85 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL7626877 | 0.85 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL27434176 | 0.85 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL5323807 | 0.85 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257998-A1 | A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2020-12-30 | — | — | WO | disclosed |