Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | GLA | P06280 | 2/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.80 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.80 |
| ▸ | RECQL | P46063 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18310362 | 0.90 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL8738070 | 0.90 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| Hydrochloric Acid SCHEMBL17476487 | 0.89 | TOP1 (1.00) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL27432677 | 0.89 | TOP1 (0.77) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL7633084 | 0.89 | TOP1 (0.77) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL27432679 | 0.89 | TOP1 (0.75) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL25130174 | 0.89 | TOP1 (0.78) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL20503262 | 0.88 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL17285701 | 0.88 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA | |
| SCHEMBL7626877 | 0.88 | TOP1 (0.81) | TOP1KDM4EPOLBMAPTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156754-A | Glycoconjugates of modified camptothecin derivatives (A-or B-ring linkage) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-12-05 | — | — | US | disclosed |
| EP-0939765-A1 | GLYCOCONJUGATES OF MODIFIED CAMPTOTHECIN DERIVATIVES (A- OR B-RING LINKAGE) | BAYER AG (DE) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998014468-A1 | GLYCOCONJUGATES OF MODIFIED CAMPTOTHECIN DERIVATIVES (A- OR B-RING LINKAGE) | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-09 | — | — | WO | disclosed |