Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19605842 | 0.80 | ALDH1A1 (0.49) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL21399875 | 0.80 | POLB (0.46) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL6255733 | 0.79 | NPC1 (0.59) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL2666190 | 0.78 | ALDH1A1 (0.71) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL21099387 | 0.77 | ALDH1A1 (0.52) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL13588766 | 0.75 | NPC1 (0.70) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL29294710 | 0.74 | GAA (0.55) | ALDH1A1NPC1RAB9APKMPOLB | |
| SCHEMBL14297740 | 0.74 | JAK2 (0.37) | ALDH1A1LMNANPC1RAB9APOLB | |
| SCHEMBL6793174 | 0.73 | POLB (0.69) | ALDH1A1LMNANPC1RAB9APKM | |
| SCHEMBL6799235 | 0.73 | POLB (0.69) | ALDH1A1LMNANPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263832-A1 | E3 LIGASE BINDERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |