Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845492 | 0.91 | DDB1 (0.53) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL21070612 | 0.85 | CRBN (0.51) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL19481342 | 0.83 | DDB1 (0.71) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL29378386 | 0.83 | DDB1 (0.71) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL23418286 | 0.83 | CRBN (0.52) | CRBNDDB1HDAC1HDAC2HDAC3 | |
| SCHEMBL19475746 | 0.79 | STAT3 (0.49) | CRBNDDB1HDAC1HDAC2STAT3 | |
| SCHEMBL21070939 | 0.79 | CRBN (0.77) | CRBNDDB1STAT3CA2 | |
| SCHEMBL21274933 | 0.79 | LRRK2 (0.52) | CRBNDDB1HDAC1STAT3CA2 | |
| SCHEMBL9988737 | 0.78 | DDB1 (0.64) | CRBNDDB1HDAC1HDAC2TNF | |
| SCHEMBL22845577 | 0.78 | DDB1 (0.67) | CRBNDDB1TNFIL1BTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |