Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 11/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 11/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.45 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845467 | 0.91 | CRBN (0.49) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL23418286 | 0.84 | CRBN (0.52) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL21070612 | 0.84 | CRBN (0.51) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL21274933 | 0.84 | LRRK2 (0.52) | DDB1CRBNHDAC1STAT3 | |
| SCHEMBL29402619 | 0.83 | DDB1 (0.76) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL1961607 | 0.83 | DDB1 (0.76) | DDB1CRBNHDAC1HDAC2STAT3 | |
| Hydrochloric Acid SCHEMBL29262211 | 0.83 | DDB1 (0.76) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL22649829 | 0.83 | DDB1 (0.76) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL22555985 | 0.81 | CRBN (0.45) | DDB1CRBNHDAC1HDAC2STAT3 | |
| SCHEMBL21070939 | 0.80 | CRBN (0.77) | DDB1CRBNSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |