Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 2/20 | 0.91 |
| ▸ | STS | P08842 | 8/20 | 0.91 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.91 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.91 |
| ▸ | LMNA | P02545 | 2/20 | 0.91 |
| ▸ | MAPT | P10636 | 2/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.91 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.91 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.91 |
| ▸ | SHBG | P04278 | 1/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.91 |
| ▸ | PGR | P06401 | 1/20 | 0.91 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.91 |
| ▸ | AR | P10275 | 1/20 | 0.91 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.91 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.91 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.91 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.91 |
| ▸ | SNCA | P37840 | 1/20 | 0.91 |
| ▸ | HTR2B | P41595 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estrone SCHEMBL6693553 | 1.00 | STS (0.91) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL669802 | 0.99 | STS (0.89) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL8901907 | 0.99 | STS (0.89) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL22551313 | 0.99 | STS (0.89) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL628643 | 0.95 | STS (0.87) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL157262 | 0.95 | CYP19A1 (1.00) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL12054811 | 0.95 | CYP19A1 (1.00) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL5028951 | 0.95 | CYP19A1 (1.00) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL15079288 | 0.95 | CYP19A1 (1.00) | STSHSD17B1CYP19A1LMNAMAPT | |
| Estrone SCHEMBL7831317 | 0.95 | CYP19A1 (1.00) | STSHSD17B1CYP19A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2517 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594237-B2 | Mucoadhesive gel composition | Viramal Limited (GB) | 2026-04-07 | — | — | US | claimed |
| EP-4692783-A1 | BIOMARKER AND SYSTEM FOR PREDICTING EVOLUTION INTO ACLF OR DEATH OF ACLF PATIENT, AND USES THEREOF | Shanghai Ganning Medical and Technology Co., Ltd (CN) | 2026-02-11 | — | — | EP | claimed |
| US-20250387389-A1 | METHODS OF TREATING DISEASE WITH LEVOKETOCONAZOLE | XERIS PHARMACEUTICALS, INC. (US) | 2025-12-25 | — | — | US | claimed |
| US-12377096-B2 | Methods of treating disease with levoketoconazole | XERIS PHARMACEUTICALS, INC. (US) | 2025-08-05 | — | — | US | claimed |
| CN-119510604-A | Biomarker for predicting whether ACLF patient will die, system and application thereof | 上海甘宁医疗科技有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119470683-A | Biomarker for predicting whether ACLF will be formed, system and application thereof | 上海甘宁医疗科技有限公司 | 2025-02-18 | — | — | CN | claimed |
| EP-4176256-B1 | EGG DETERMINING METHOD AND DEVICE | IN OVO HOLDING B V (NL) | 2025-01-29 | — | — | EP | claimed |
| CN-119339933-A | Age estimation method based on multidimensional data | 中国科学院北京基因组研究所(国家生物信息中心) | 2025-01-21 | — | — | CN | claimed |
| CN-119324053-A | Model and index for evaluating aging delaying effect of estrogen replacement therapy and application of model and index | 中国科学院北京基因组研究所(国家生物信息中心) | 2025-01-17 | — | — | CN | claimed |
| WO-2024198046-A1 | BIOMARKER AND SYSTEM FOR PREDICTING EVOLUTION INTO ACLF OR DEATH OF ACLF PATIENT, AND USES THEREOF | 上海甘宁医疗科技有限公司 | 2024-10-03 | — | — | WO | claimed |
| CN-1041528-A | HORMONE PREPARATION AND METHOD | JENCAP RESEARCH LTD (CA) | 1990-04-25 | — | — | CN | claimed |
| EP-0354921-A1 | COMPOSITIONS AND METHODS OF EFFECTING CONTRACEPTION AND CONTROL OF BREAST CANCER. | APPLIED MED RES (US) | 1990-02-21 | — | — | EP | claimed |
| US-4855305-A | Compositions and methods of effecting contraception utilizing melatonin | APPLIED MEDICAL RESEARCH (US) | 1989-08-08 | — | — | US | claimed |
| US-4826831-A | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens | PRE JAY HOLDINGS LIMITED (CA) | 1989-05-02 | — | — | US | claimed |
| EP-0309263-A2 | Hormone composition and use | JENCAP RESEARCH LIMITED (CA) | 1989-03-29 | — | — | EP | claimed |
| WO-1988007370-A1 | COMPOSITIONS AND METHODS OF EFFECTING CONTRACEPTION AND CONTROL OF BREAST CANCER | APPLIED MEDICAL RESEARCH, LTD. (US) | 1988-10-06 | — | — | WO | claimed |
| CN-88101379-A | Methods and compositions for effecting contraception | — | 1988-10-05 | — | — | CN | claimed |
| US-4629449-A | Vaginal dispenser for dispensing beneficial hormone | ALZA CORPORATION (US) | 1986-12-16 | — | — | US | claimed |
| US-4628051-A | LOW DOSAGE OF ESTROGEN AND PROGESTOGEN | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-09 | — | — | US | claimed |
| US-4402695-A | Device for delivering agent in vagina | ALZA CORPORATION (US) | 1983-09-06 | — | — | US | claimed |