Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21070392 | 0.89 | MEN1 (0.41) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL25122932 | 0.89 | MEN1 (0.41) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL31727914 | 0.89 | MEN1 (0.41) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL25337449 | 0.89 | MEN1 (0.41) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL31702383 | 0.88 | MEN1 (0.39) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL29751250 | 0.87 | MEN1 (0.39) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL24607332 | 0.87 | MEN1 (0.39) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL20840301 | 0.86 | DCTPP1 (0.43) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL21998074 | 0.85 | HCRTR2 (0.44) | MEN1KMT2ALMNAHCRTR2HCRTR1 | |
| SCHEMBL25338661 | 0.84 | MEN1 (0.37) | MEN1KMT2ALMNAHCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |