Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294455 | 1.00 | DHODH (0.42) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30294667 | 0.93 | DHODH (0.41) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL22853123 | 0.93 | DHODH (0.41) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL22853437 | 0.93 | ALDH1A1 (0.40) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30294464 | 0.93 | ALDH1A1 (0.40) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL22853162 | 0.92 | DHODH (0.40) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30294834 | 0.92 | DHODH (0.40) | DHODHSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL30294668 | 0.89 | DHODH (0.39) | DHODHSMN1; SMN2NPC1GAATP53 | |
| SCHEMBL22853113 | 0.89 | DHODH (0.39) | DHODHSMN1; SMN2NPC1GAATP53 | |
| SCHEMBL22853160 | 0.89 | ALDH1A1 (0.45) | DHODHSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |