Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22854158 | 0.93 | HRH4 (0.48) | DRD2DRD3HRH4AKR1C3NPC1 | |
| SCHEMBL22854231 | 0.92 | HRH4 (0.49) | DRD2DRD3HRH4MMP9MEN1 | |
| SCHEMBL22854230 | 0.91 | HRH4 (0.40) | HRH4MMP9MEN1KMT2AGPR183 | |
| SCHEMBL22854239 | 0.90 | MMP9 (0.37) | HRH4MMP9NPC1RAB9AGPR183 | |
| SCHEMBL22831725 | 0.90 | HRH4 (0.46) | DRD2DRD3HRH4AKR1C3MAPK14 | |
| SCHEMBL22854138 | 0.90 | NPC1 (0.50) | DRD2DRD3HRH4NPC1RAB9A | |
| SCHEMBL22854139 | 0.87 | HRH4 (0.49) | HRH4MEN1KMT2AGPR183 | |
| SCHEMBL22854328 | 0.86 | HRH4 (0.48) | HRH4NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22854159 | 0.86 | HRH4 (0.36) | DRD2DRD3HRH4MMP9MEN1 | |
| SCHEMBL22854234 | 0.84 | HRH4 (0.48) | DRD2DRD3HRH4TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200407365-A1 | INDOLE-2-CARBONYL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HEPATITIS B | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200407365-A1 | INDOLE-2-CARBONYL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HEPATITIS B | IDO2, IDO1, SLC10A1 | DRD2 2609/4885DRD3 3078/4885HRH4 1032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.