Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22854304 | 0.88 | ALOX5AP (0.43) | EGLN1ALDH1A1HPGDHDAC4IRAK4 | |
| SCHEMBL22854250 | 0.86 | HDAC4 (0.36) | EGLN1ALDH1A1HPGDHDAC4MAOA | |
| SCHEMBL1418614 | 0.75 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL107626 | 0.75 | BACE1 (0.42) | BACE1ALDH1A1GRM4DPP4DPP9 | |
| SCHEMBL22854302 | 0.74 | ALOX5AP (0.39) | EGLN1ALDH1A1HPGDHDAC4IRAK4 | |
| SCHEMBL22854405 | 0.74 | ALOX5AP (0.39) | EGLN1ALDH1A1HPGDHDAC4IRAK4 | |
| SCHEMBL12780298 | 0.72 | DPP4 (0.40) | BACE1NPC1RAB9ADPP4DPP9 | |
| SCHEMBL19480931 | 0.70 | ALOX5AP (0.43) | HDAC4ALOX5APFEN1 | |
| SCHEMBL23732706 | 0.70 | SMN1; SMN2 (0.44) | EGLN1ALDH1A1HPGDDYRK1AFPR2 | |
| SCHEMBL1395991 | 0.69 | AGBL2 (0.41) | BACE1DPP4DPP9BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264081-A1 | PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2020-12-30 | — | — | WO | disclosed |