Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 11/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | MST1R | Q04912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2287619 | 0.93 | MET (0.40) | METAXLMERTKKDRKIT | |
| SCHEMBL2282574 | 0.92 | MET (0.36) | METAXLKDRKITFLT3 | |
| SCHEMBL2288195 | 0.91 | AXL (0.38) | METAXLMERTKKDRKIT | |
| SCHEMBL2288067 | 0.88 | KDR (0.33) | METAXLMERTKKDRKIT | |
| SCHEMBL2285721 | 0.85 | KDR (0.35) | METAXLMERTKKDRKIT | |
| SCHEMBL12376882 | 0.82 | MET (0.55) | METAXLMERTKKDRKIT | |
| SCHEMBL2287759 | 0.82 | MET (0.39) | METAXLMERTKKDRKIT | |
| SCHEMBL2285671 | 0.81 | MET (0.40) | METAXLKDRKITFLT3 | |
| SCHEMBL2284158 | 0.80 | MET (0.39) | METAXLMERTKKDRKIT | |
| SCHEMBL2285176 | 0.78 | MET (0.41) | METAXLKDRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | MET 142/4885AXL 102/4885MERTK 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.