Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26456365 | 0.85 | SIGMAR1 (0.42) | TAAR1SIGMAR1MAPTKDM4EHRH3 | |
| SCHEMBL22794502 | 0.85 | TAAR1 (0.52) | TAAR1SIGMAR1TMEM97ATMMAPT | |
| SCHEMBL26369891 | 0.83 | AOC3 (0.48) | SIGMAR1MAPTCYP1A2TSHRNFKB1 | |
| SCHEMBL22856070 | 0.83 | HRH3 (0.39) | TAAR1SIGMAR1CYP1A2HRH3 | |
| SCHEMBL23560444 | 0.80 | TAAR1 (0.47) | TAAR1SIGMAR1TMEM97ATMMAPT | |
| SCHEMBL22856373 | 0.80 | SIGMAR1 (0.39) | SIGMAR1TMEM97HIF1ALMNASMN1; SMN2 | |
| SCHEMBL25883722 | 0.80 | HRH3 (0.37) | TAAR1SIGMAR1CYP1A2SMN1; SMN2HRH3 | |
| SCHEMBL23560371 | 0.80 | HRH3 (0.37) | TAAR1SIGMAR1CYP1A2HRH3 | |
| SCHEMBL26408085 | 0.80 | TAAR1 (0.43) | TAAR1SIGMAR1TMEM97ATMMAPT | |
| SCHEMBL26456364 | 0.79 | HRH3 (0.64) | TAAR1SIGMAR1MAPTTP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |