Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23267783 | 0.98 | EPHX1 (0.44) | EPHX1HTR1BTSHREPHX2ALDH1A1 | |
| SCHEMBL9947082 | 0.97 | — | — | |
| SCHEMBL23267022 | 0.95 | EPHX1 (0.46) | EPHX1HTR1BTSHREPHX2ALDH1A1 | |
| SCHEMBL23267823 | 0.95 | EPHX1 (0.46) | EPHX1HTR1BTSHREPHX2ALDH1A1 | |
| SCHEMBL22930461 | 0.93 | EPHX1 (0.50) | EPHX1HTR1BTSHREPHX2MEN1 | |
| SCHEMBL22703713 | 0.91 | EPHX1 (0.54) | EPHX1TSHREPHX2MEN1THRB | |
| SCHEMBL22560669 | 0.90 | EPHX1 (0.40) | EPHX1HTR1BTSHREPHX2ALDH1A1 | |
| SCHEMBL22856487 | 0.90 | EPHX1 (0.52) | EPHX1HTR1BTSHRALDH1A1MEN1 | |
| SCHEMBL22343740 | 0.90 | EPHX1 (0.52) | EPHX1HTR1BTSHREPHX2MEN1 | |
| SCHEMBL22703712 | 0.88 | EPHX1 (0.50) | EPHX1HTR1BTSHREPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220425-A1 | BCL-XL/BCL-2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2021077010-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | ARVINAS OPERATIONS, INC. (US) | 2021-04-22 | — | — | WO | disclosed |
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |