Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681375 | 0.97 | EPHX1 (0.55) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL13668221 | 0.95 | EPHX1 (0.52) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL17974512 | 0.95 | EPHX1 (0.52) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL2599824 | 0.90 | EPHX1 (0.59) | EPHX1TSHRALDH1A1HTR1BMAPT | |
| SCHEMBL22856548 | 0.90 | EPHX1 (0.46) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL23267783 | 0.88 | EPHX1 (0.44) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL15511002 | 0.88 | EPHX1 (0.64) | EPHX1TSHRALDH1A1HTR1BMAPT | |
| SCHEMBL8979942 | 0.88 | EPHX1 (0.64) | EPHX1TSHRALDH1A1HTR1BMAPT | |
| SCHEMBL14051928 | 0.88 | EPHX1 (0.64) | EPHX1TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL13997666 | 0.88 | EPHX1 (0.56) | EPHX1TSHRCYP3A4ALDH1A1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |