Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 7/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31493955 | 1.00 | PDK1 (0.50) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL22856599 | 1.00 | PDK1 (0.50) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL22856094 | 0.89 | USP2 (0.44) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL22856437 | 0.89 | USP2 (0.44) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL23860226 | 0.88 | USP2 (0.43) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL8140489 | 0.88 | PDK1 (0.54) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL17897027 | 0.88 | PDK1 (0.54) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL30962180 | 0.87 | PDK1 (0.59) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL23807943 | 0.86 | USP2 (0.43) | PDK1USP2SMN1; SMN2EPHA2RECQL | |
| SCHEMBL22856401 | 0.86 | USP2 (0.43) | PDK1USP2SMN1; SMN2EPHA2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020264490-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |