SCHEMBL22857643

SCHEMBL22857643

Fc1c(F)c(F)c2c(-c3cc4ccccc4s3)ncnc2c1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.45
PIK3CA P42336 1/20 0.45
PIK3CB P42338 1/20 0.45
PIK3CG P48736 1/20 0.45
PRKDC P78527 1/20 0.45
JAK2 O60674 1/20 0.43
JAK3 P52333 1/20 0.43
DCK P27707 1/20 0.39
APP P05067 2/20 0.38
PLAU P00749 1/20 0.38
CYP19A1 P11511 1/20 0.37
ADK P55263 1/20 0.37
FGFR1 P11362 2/20 0.37
FGFR4 P22455 1/20 0.37
NQO1 P15559 1/20 0.37
NQO2 P16083 1/20 0.37
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36
STK17B O94768 2/20 0.36
STK17A Q9UEE5 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24003191 0.81 APP (0.38) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL28877294 0.72 ADORA2A (0.39) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL28741897 0.70
SCHEMBL22857630 0.70 PIK3CD (0.39) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL23077807 0.69 PIK3CD (0.45) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL28877270 0.69 PIK3CA (0.38) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL22342532 0.68 ADORA2A (0.61) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL24473302 0.67 PLAU (0.41) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL24003193 0.67 PIK3CD (0.34) PIK3CDPIK3CAPIK3CBPIK3CGPRKDC
SCHEMBL845603 0.67 APP (0.63) APPCYP19A1NQO1NQO2ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220213131-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2022-07-07 US disclosed
US-20210002311-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210002311-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, OTC PIK3CD 3398/4885PIK3CA 4322/4885PIK3CB 4240/4885
US-20220213131-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, LOXL1, OCIAD2 PIK3CD 4047/4885PIK3CA 4332/4885PIK3CB 4609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.