Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858331 | 0.78 | AAK1 (0.39) | AAK1DRD2MAPK14 | |
| SCHEMBL35210564 | 0.71 | AAK1 (0.35) | USP30AAK1PRMT5WDR77MAPK14 | |
| SCHEMBL27164468 | 0.69 | USP30 (0.37) | USP30AAK1PRMT5WDR77MAPK14 | |
| SCHEMBL24049966 | 0.69 | AAK1 (0.36) | USP30AAK1PRMT5WDR77 | |
| SCHEMBL22858338 | 0.67 | STK17B (0.37) | AAK1 | |
| SCHEMBL22858298 | 0.66 | MAPK14 (0.41) | AAK1DRD2MAPK14 | |
| SCHEMBL26970589 | 0.65 | USP30 (0.34) | USP30AAK1PRMT5WDR77 | |
| SCHEMBL30863611 | 0.65 | AAK1 (0.39) | USP30AAK1PRMT5WDR77MAPK14 | |
| SCHEMBL29341854 | 0.65 | GSK3B (0.38) | USP30AAK1PRMT5WDR77MAPK14 | |
| SCHEMBL24622449 | 0.65 | AAK1 (0.46) | USP30AAK1PRMT5WDR77DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000957-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 北京国鸿生物医药科技有限公司 | 2021-01-07 | — | — | WO | disclosed |