Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858712 | 1.00 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858703 | 1.00 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL29608772 | 1.00 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL29608815 | 1.00 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858854 | 0.95 | MAP4K1 (0.90) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22859156 | 0.92 | MAP4K1 (0.86) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858711 | 0.91 | MAP4K1 (0.83) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858775 | 0.90 | MAP4K1 (0.81) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22858869 | 0.90 | MAP4K1 (0.81) | MAP4K1MAPK1JAK2JAK1TYK2 | |
| SCHEMBL22858708 | 0.90 | MAP4K1 (0.81) | MAP4K1MAPK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114096536-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-02-25 | — | — | CN | disclosed |
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |