Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858703 | 0.91 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858712 | 0.91 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL29608815 | 0.91 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL29608772 | 0.91 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858702 | 0.91 | MAP4K1 (1.00) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858854 | 0.90 | MAP4K1 (0.90) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858830 | 0.88 | MAP4K1 (0.77) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22859156 | 0.88 | MAP4K1 (0.86) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL22858924 | 0.88 | MAP4K1 (0.77) | MAP4K1MAPK1CYP3A4JAK2JAK1 | |
| SCHEMBL29609138 | 0.88 | MAP4K1 (0.77) | MAP4K1MAPK1CYP3A4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |