Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.65 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 10/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911419 | 1.00 | MAP4K1 (0.65) | MAP4K1KDM1AJAK3MAP3K11CDK1 | |
| SCHEMBL22858710 | 0.91 | MAP4K1 (0.53) | MAP4K1KDM1AJAK3MAP3K11CDK1 | |
| SCHEMBL29911361 | 0.91 | MAP4K1 (0.53) | MAP4K1KDM1AJAK3MAP3K11CDK1 | |
| SCHEMBL22858763 | 0.88 | MAP4K1 (0.72) | MAP4K1JAK3MAP3K11 | |
| SCHEMBL22858994 | 0.86 | MAP4K1 (0.69) | MAP4K1JAK3MAP3K11 | |
| SCHEMBL29609616 | 0.83 | MAP4K1 (0.66) | MAP4K1JAK3MAP3K11 | |
| SCHEMBL22858993 | 0.83 | MAP4K1 (0.66) | MAP4K1JAK3MAP3K11 | |
| SCHEMBL29608972 | 0.83 | MAP4K1 (0.86) | MAP4K1MAP3K11 | |
| SCHEMBL22858685 | 0.83 | MAP4K1 (0.86) | MAP4K1MAP3K11 | |
| SCHEMBL22858768 | 0.82 | MAP4K1 (0.75) | MAP4K1JAK3MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |