Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609616 | 1.00 | MAP4K1 (0.66) | MAP4K1MAP3K11EGLN1JAK2JAK1 | |
| SCHEMBL22858801 | 0.94 | MAP4K1 (0.71) | MAP4K1MAP3K11EGLN1JAK2JAK1 | |
| SCHEMBL29608808 | 0.94 | MAP4K1 (0.71) | MAP4K1MAP3K11EGLN1JAK2JAK1 | |
| SCHEMBL22858994 | 0.90 | MAP4K1 (0.69) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL22858763 | 0.89 | MAP4K1 (0.72) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592767 | 0.87 | MAP4K1 (0.49) | MAP4K1MAP3K11EGLN1JAK2JAK1 | |
| SCHEMBL22859025 | 0.86 | MAP4K1 (0.49) | MAP4K1MAP3K11EGLN1JAK2JAK1 | |
| SCHEMBL22858762 | 0.83 | MAP4K1 (0.65) | MAP4K1MAP3K11JAK3 | |
| SCHEMBL29911419 | 0.83 | MAP4K1 (0.65) | MAP4K1MAP3K11JAK3 | |
| SCHEMBL22858685 | 0.83 | MAP4K1 (0.86) | MAP4K1MAP3K11MAPK1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |