Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858695 | 0.95 | MAP4K1 (0.51) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858721 | 0.92 | MAP4K1 (0.51) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858799 | 0.85 | MAP4K1 (0.57) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859007 | 0.85 | MAP4K1 (0.49) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858875 | 0.85 | MAP4K1 (0.62) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858740 | 0.83 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858709 | 0.82 | MAP4K1 (0.75) | MAP4K1SMOJAK2JAK1TYK2 | |
| SCHEMBL22858982 | 0.82 | MAP4K1 (0.40) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859187 | 0.80 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859064 | 0.78 | MAP4K1 (0.55) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |