Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29608774 | 0.88 | MAP4K1 (0.46) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL28709865 | 0.88 | MAP4K1 (0.46) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL22858747 | 0.86 | MAP4K1 (0.70) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL29607897 | 0.86 | MAP4K1 (0.70) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL22858995 | 0.83 | MAP4K1 (0.52) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL22858695 | 0.82 | MAP4K1 (0.51) | MAP4K1BRD4JAK2JAK3JAK1 | |
| SCHEMBL22858879 | 0.79 | MAP4K1 (0.50) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL22858721 | 0.79 | MAP4K1 (0.51) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL22858709 | 0.78 | MAP4K1 (0.75) | MAP4K1JAK2JAK3JAK1TYK2 | |
| SCHEMBL29608953 | 0.76 | MAP4K1 (0.47) | MAP4K1JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |