Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | BAD | Q92934 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344153 | 0.80 | HTT (0.46) | HTTMAPK1MAPTSYKCCNA2 | |
| SCHEMBL4712352 | 0.80 | HTT (0.51) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4846993 | 0.77 | MAPK1 (0.39) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28039439 | 0.77 | HTT (0.52) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL26107898 | 0.75 | HTT (0.47) | HTTMAPK1CDK9SYKCCNA2 | |
| SCHEMBL30596936 | 0.75 | HTT (0.47) | HTTMAPK1CDK9SYKCCNA2 | |
| SCHEMBL6619405 | 0.75 | HTT (0.42) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1521589 | 0.75 | HTT (0.51) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4854253 | 0.75 | HTT (0.72) | HTTMAPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6617756 | 0.74 | HTT (0.54) | HTTMAPK1SYKPIM1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021003314-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC. (US) | 2021-01-07 | — | — | WO | disclosed |