Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703528 | 0.89 | NPC1 (0.75) | NPC1EPHX2EPHX1GAAKEAP1 | |
| SCHEMBL18855748 | 0.87 | NPC1 (0.71) | NPC1EPHX2EPHX1GAAKEAP1 | |
| SCHEMBL22890944 | 0.81 | NPC1 (0.67) | NPC1HRH3SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL14681493 | 0.79 | KEAP1 (0.44) | EPHX2HRH3KEAP1SMN1; SMN2CYP3A4 | |
| SCHEMBL6449789 | 0.78 | EPHX2 (0.42) | EPHX2HRH3KEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5293921 | 0.77 | KEAP1 (0.58) | HRH3KEAP1SMN1; SMN2CYP3A4KCNH2 | |
| Hydrochloric Acid SCHEMBL28373903 | 0.76 | NPC1 (0.55) | NPC1EPHX2HRH3KCNH2SIGMAR1 | |
| SCHEMBL13086520 | 0.74 | NPC1 (0.52) | NPC1EPHX2HRH3KEAP1SMN1; SMN2 | |
| SCHEMBL13939521 | 0.74 | NPC1 (0.88) | NPC1HRH3KCNH2CYP1A2 | |
| SCHEMBL16016535 | 0.74 | NPC1 (0.88) | NPC1HRH3KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11021492-B2 | mTORC modulators and uses thereof | AEOVIAN PHARMACEUTICALS, INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-20210002300-A1 | MTORC MODULATORS AND USES THEREOF | AEOVIAN PHARMACEUTICALS, INC. | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002300-A1 | MTORC MODULATORS AND USES THEREOF | MTOR, RICTOR, RPTOR | NPC1 1541/4885EPHX2 4859/4885HRH3 3363/4885 |
| US-11021492-B2 | mTORC modulators and uses thereof | MTOR, RICTOR, RPTOR | NPC1 1541/4885EPHX2 4859/4885HRH3 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.