Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862463 | 0.82 | CYP11B1 (0.44) | LMNAHTTCYP11B1CYP11B2BRD4 | |
| SCHEMBL22862658 | 0.81 | MAPK14 (0.37) | LMNAHTTCYP11B1CYP11B2BRD4 | |
| SCHEMBL22862469 | 0.79 | CYP11B1 (0.39) | LMNAHTTCYP11B1CYP11B2BRD4 | |
| SCHEMBL22862654 | 0.79 | HDAC4 (0.39) | LMNAHTTCYP11B1CYP11B2HDAC4 | |
| SCHEMBL22862877 | 0.78 | SIGMAR1 (0.39) | HDAC4BRD4SIGMAR1DRD4CACNA1G | |
| SCHEMBL22862599 | 0.77 | HDAC4 (0.39) | LMNAHTTCYP11B1CYP11B2HDAC4 | |
| SCHEMBL22862462 | 0.75 | CYP11B1 (0.46) | LMNAHTTCYP11B1CYP11B2BRD4 | |
| SCHEMBL29490245 | 0.73 | HDAC3 (0.33) | HDAC4BRD4 | |
| SCHEMBL22862712 | 0.73 | HDAC3 (0.33) | HDAC4BRD4 | |
| SCHEMBL24704432 | 0.71 | HDAC3 (0.35) | LMNAHDAC4BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976009-A2 | BAX INHIBITORS AND USES THEREOF | Case Western Reserve University (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2021002986-A2 | BAX INHIBITORS AND USES THEREOF | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-01-07 | — | — | WO | disclosed |