Sugi Predict

Sugi Predict / Compounds / SCHEMBL2286328

SCHEMBL2286328

SCHEMBL2286328

O=C1CN(c2ncc(-c3cccc(Nc4ccc(Cl)cn4)n3)o2)CCN1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CCNT1 O60563 1/20 0.39
▸ CDK4 P11802 1/20 0.39
▸ CCND1 P24385 1/20 0.39
▸ CCND3 P30281 1/20 0.39
▸ CDK9 P50750 1/20 0.39
▸ CDK6 Q00534 1/20 0.39
▸ KARS1 Q15046 5/20 0.36
▸ SYK P43405 1/20 0.35
▸ PIM1 P11309 2/20 0.35
▸ PIM3 Q86V86 1/20 0.35
▸ PIM2 Q9P1W9 1/20 0.35
▸ ADRA2A P08913 1/20 0.35
▸ ADRA2B P18089 1/20 0.35
▸ ADRA2C P18825 1/20 0.35
▸ GRM5 P41594 1/20 0.34
▸ AOC3 Q16853 1/20 0.34
▸ SLC2A1 P11166 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2227650 0.90 AOC3 (0.37) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL13823522 0.89 CCNT1 (0.41) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL14673613 0.86 KARS1 (0.41) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL16519334 0.86 CDK4 (0.38) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL14673612 0.85 KARS1 (0.52) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL2352796 0.84 GRM5 (0.41) CCNT1KARS1ADRA2AADRA2BADRA2C
SCHEMBL2225041 0.82 KARS1 (0.53) KARS1SYK
SCHEMBL14673910 0.81 KARS1 (0.40) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL14673822 0.81 KARS1 (0.42) CCNT1CDK4CCND1CCND3CDK9
SCHEMBL14673765 0.81 ABL1 (0.39) CCNT1CDK4CCND1CCND3CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2523952-B1 OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2015-03-04 — — EP claimed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US claimed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US claimed
EP-2523952-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB Science (FR) 2012-11-21 — — EP claimed
WO-2011086085-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2011-07-21 — — WO claimed
EP-2523952-B1 OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2015-03-04 — — EP disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-8962665-B2 Thiazole and oxazole kinase inhibitors AB SCIENCE (FR) 2015-02-24 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS AB SCIENCE (FR) 2013-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035331-A1 THIAZOLE AND OXAZOLE KINASE INHIBITORS SYK, LTK, MERTK CCNT1 2633/4885CDK4 217/4885CCND1 1586/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.