Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 5/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.32 |
| ▸ | NEU4 | Q8WWR8 | 2/20 | 0.32 |
| ▸ | NEU3 | Q9UQ49 | 2/20 | 0.32 |
| ▸ | NEU2 | Q9Y3R4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868111 | 0.90 | SRC (0.43) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868154 | 0.89 | GGPS1 (0.42) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868120 | 0.88 | GGPS1 (0.43) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL25983194 | 0.88 | HSP90AA1 (0.43) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868156 | 0.88 | HDAC1 (0.38) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868174 | 0.83 | SRC (0.43) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868181 | 0.82 | HDAC3 (0.44) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL25983242 | 0.81 | SRC (0.34) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868131 | 0.81 | HDAC8 (0.41) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL22868051 | 0.80 | L3MBTL1 (0.39) | HDAC8HDAC6HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11654137-B2 | 3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same | GEORGIA TECH RESEARCH CORPORATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-20210000811-A1 | 3-(HYDROXY)-PYRIDIN-4(1H)-ONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | GEORGIA TECH RESEARCH CORPORATION (US) | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11654137-B2 | 3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same | KDM1B, KDM3A, KDM1A | HDAC8 194/4885HDAC6 2960/4885HDAC1 212/4885 |
| US-20210000811-A1 | 3-(HYDROXY)-PYRIDIN-4(1H)-ONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | KDM1B, KDM3A, KDM1A | HDAC8 194/4885HDAC6 2960/4885HDAC1 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.