Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914321 | 0.78 | CA1 (0.38) | KDM4ESMN1; SMN2MAPTCHRNB2CHRNA4 | |
| SCHEMBL10183439 | 0.77 | KDM4E (0.38) | KDM4ESMN1; SMN2MAPTCHRNB2CHRNA4 | |
| SCHEMBL8144693 | 0.71 | HTR2A (0.41) | MAPTHPGDALDH1A1MEN1ALOX12 | |
| SCHEMBL8520772 | 0.69 | EPHX2 (0.55) | KDM4ESMN1; SMN2MAPTAADATNPSR1 | |
| SCHEMBL9835145 | 0.68 | RCE1 (0.47) | SMN1; SMN2MAPTLMNAHTTHPGD | |
| SCHEMBL12253322 | 0.67 | NOS3 (0.34) | AADATCHRNB2CHRNA4HPGDALOX15 | |
| SCHEMBL464509 | 0.67 | EPHX2 (0.37) | KDM4ESMN1; SMN2MAPTCHRNB2CHRNA4 | |
| SCHEMBL464506 | 0.65 | EPHX2 (0.36) | KDM4ESMN1; SMN2MAPTCHRNB2CHRNA4 | |
| SCHEMBL31705254 | 0.65 | KDM1A (0.41) | HTR2CSLC6A2 | |
| SCHEMBL18325979 | 0.64 | CYP2A6 (0.36) | SMN1; SMN2CHRNB2CHRNA4HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |