Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 11/20 | 0.38 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29581347 | 1.00 | HSD17B1 (0.55) | HSD17B1HSD17B2MAPTNPC1LMNA | |
| SCHEMBL23289627 | 0.74 | CNR2 (0.44) | HSD17B1HSD17B2MAPTNPC1LMNA | |
| SCHEMBL22868116 | 0.73 | HSD17B2 (0.77) | HSD17B1HSD17B2MAPTNPC1LMNA | |
| SCHEMBL23274029 | 0.72 | MEN1 (0.41) | MAPTNPC1LMNAGAARAB9A | |
| SCHEMBL22867228 | 0.71 | HSD17B2 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL29582435 | 0.71 | HSD17B2 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL2391319 | 0.70 | CXCR2 (0.53) | HSD17B2MAPTNPC1LMNAGAA | |
| SCHEMBL18829298 | 0.69 | HPGD (0.43) | MAPTNPC1GAARAB9ALCK | |
| SCHEMBL25969748 | 0.67 | MEN1 (0.47) | MAPTNPC1LMNAGAARAB9A | |
| SCHEMBL22868075 | 0.67 | GAA (0.42) | HSD17B1HSD17B2MAPTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |