Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 4/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22867218 | 0.85 | HSD17B2 (0.67) | HSD17B2HSD17B1 | |
| SCHEMBL22868119 | 0.78 | HSD17B2 (0.76) | HSD17B2HSD17B1POLBALDH1A1KDM4E | |
| SCHEMBL22868116 | 0.77 | HSD17B2 (0.77) | HSD17B2HSD17B1POLBALDH1A1KDM4E | |
| SCHEMBL10964818 | 0.68 | POLB (0.44) | POLBALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL22867215 | 0.66 | HSD17B2 (1.00) | HSD17B2HSD17B1 | |
| SCHEMBL30359614 | 0.65 | HSD17B2 (0.60) | HSD17B2HSD17B1KDM4E | |
| SCHEMBL22867243 | 0.65 | HSD17B2 (0.60) | HSD17B2HSD17B1KDM4E | |
| SCHEMBL26351690 | 0.64 | POLB (0.44) | POLBALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL22867897 | 0.63 | HSD17B2 (0.74) | HSD17B2HSD17B1 | |
| SCHEMBL30359599 | 0.63 | HSD17B2 (0.74) | HSD17B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |