Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 7/20 | 0.76 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.76 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868116 | 0.92 | HSD17B2 (0.77) | HSD17B2HSD17B1RAB9ANPC1MAPT | |
| SCHEMBL22867215 | 0.87 | HSD17B2 (1.00) | HSD17B2HSD17B1 | |
| SCHEMBL22867228 | 0.79 | HSD17B2 (1.00) | HSD17B2HSD17B1 | |
| SCHEMBL29582435 | 0.79 | HSD17B2 (1.00) | HSD17B2HSD17B1 | |
| SCHEMBL22868117 | 0.78 | HSD17B2 (0.48) | HSD17B2HSD17B1RAB9AMAPTKDM4E | |
| SCHEMBL8438099 | 0.69 | HSD17B1 (0.47) | HSD17B2HSD17B1RAB9ANPC1MAPT | |
| SCHEMBL22867218 | 0.65 | HSD17B2 (0.67) | HSD17B2HSD17B1 | |
| SCHEMBL22868072 | 0.63 | HSD17B1 (0.55) | HSD17B2HSD17B1RAB9ANPC1MAPT | |
| SCHEMBL29581347 | 0.63 | HSD17B1 (0.55) | HSD17B2HSD17B1RAB9ANPC1MAPT | |
| SCHEMBL11120767 | 0.61 | SPR (0.49) | RAB9AMAPTLMNAGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |